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| ![]() Nogales (Pop: 20,800) is the county seat of Santa Cruz County. It borders the city of Nogales, Sonora, Mexico, and is Arizona's largest international border town. The southern terminus of Interstate 19 is located in Nogales at the U.S.-Mexico border. The name "Nogales" is derived from the Spanish word for "walnut" or "walnut tree." It refers to the large stands of walnut trees that once stood in the mountain pass where Nogales is located. In 1841, a land grant from the Mexican government to the Elias family established Los Nogales de Elias. In 1880, Russian immigrant Jacob Isaacson built a trading post at present-day Nogales. The U.S. Postal Service opened the Isaacson Post Office but renamed it as Nogales in 1883.
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